ARV 825

Name	ARV-825
Synonyms	ARV825 ARV-825 AVR-825 CS-2252 ARV 825 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 4-(4-chlorophenyl)-N-[4-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]phenyl]-2,3,9-trimethyl-, (6S)-
CAS	1818885-28-7

Molecular Formula	C46H47ClN8O9S
Molar Mass	923.43
Density	1.47±0.1 g/cm3(Predicted)
Solubility	10 mM in DMSO
pKa	10.74±0.40(Predicted)
Storage Condition	2-8°C(protect from light)
In vitro study	In Burkitt's lymphoma cells, ARV-825 treatment resulted in more significant changes in c-MYC levels and downstream cell proliferation and apoptosis induction compared to other BRD4 inhibitors. Co-incubated with ARV-825 for 72 hours, ARV-825 had IC50 values in the 2-50 nM range against the cell lines tested and primary AML cells. In AML cells, ARV-825 reduces PIM1 levels and CXCR4 phosphorylation levels, and overexpression of PIM1 or CXCR4 reverses this effect.
In vivo study	In the mouse model transplanted with human leukemia cells, the leukemia burden of the mice in the ARV-825 experimental group was significantly lower than that of the control group, and the survival time was longer than that of the control group.

Last Update：2024-01-02 23:10:35

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Product Name: ARV-825 Visit Supplier Webpage Request for quotation
CAS: 1818885-28-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

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ARV 825

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